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Many patients start to feel improvements in energy, recovery, and sleep within a few weeks

In cells containing mitochondria, ALA is reduced in an NADH-dependent reaction with lipoamide dehydrogenase to form dihydrolipoic acid (DHLA), whereas in cells that lack mitochondria, ALA can instead be reduced to DHLA via NADPH with glutathione (GSH) and thioredoxin reductases (Jones et al., 2002)

A study of patients with non-alcoholic fatty liver disease (NAFLD) revealed that giving 300 mg of glutathione daily for four months resulted in significant reductions in elevated ALT (an enzyme associated with liver damage), triglycerides, and ferritin

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